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Test Code CS1CS Contactin-Associated Protein-1 (CASPR1)-IgG, Cell Binding Assay, Serum (Non-Orderable)


Specimen Required


Only orderable as part of a profile. For more information see:

-CIDP / Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum

-CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum

-DMNES / Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum


Useful For

Only orderable as part of a profile. For more information see:

CIDP / Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum

CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum

DMNES / Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum

 

Evaluating patients with suspected peripheral neuropathy

Method Name

Only orderable as part of a profile. For more information see:

-CIDP / Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum

-CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum

-DMNES / Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum

 

Cell-Binding Assay (CBA)

Reporting Name

CASPR1-IgG CBA, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Clinical Information

Contactin-associated protein-1 (CASPR1) antibody is useful in the identification of autoimmune nodopathy cases, which can resemble chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Detecting this antibody helps in selecting appropriate treatment. Patients who are CASPR1 IgG positive often do not respond well to IVIG (intravenous immunoglobulin), the standard CIDP therapy, but several have responded well to rituximab therapy. CASPR1 forms a complex with contactin-1 (CNTN1), which is important for function. Autoantibodies have been identified that can target each protein (CASPR1 or CNTN1) alone, the CNTN1/CASPR1 complex, or both. Identifying the presence of these autoantibodies is useful in evaluating patients with suspected autoimmune peripheral neuropathy.

Reference Values

Only orderable as part of a profile. For more information see:

-CIDP / Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum

-CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum

-DMNES / Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum

 

Negative

Interpretation

Seropositivity for contactin-associated protein-1 IgG is consistent with an immune mediated demyelinating neuropathy. A paraneoplastic basis should be considered, according to age, sex, and other risk factors.

Day(s) Performed

Monday through Sunday

Report Available

3 to 5 days

Specimen Retention Time

2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86255 x2

LOINC Code Information

Result ID Test Result Name Result LOINC Value
623393 CASPR1-IgG CBA, S 101448-9
624189 CASPR1/Contactin-1 Complex In Process